The need for the organ transplant is increasing in our sector of health care as more and more end stage diseases are being diagnosed. Organ transplantation may be a life-saving option, but they are not without their challenges and risks. The concept of organ transplantation is both miraculous and challenging at the same time. Whether a patient needs a new kidney, liver, heart, or lung, there are multiple issues that the patient and the family need to deal with. They involve decisions before the transplantation and medical issues postoperatively. An organ transplant bill that had been under study with the senate since 1992 was finally approved on 5 September 2007 as “A Transplantation of Human Organs and Tissues Ordinance 2007” by the Government of Pakistan, and many illegal organ donation and transplantation centers were closed down and many senior doctors involved in the act were charged against it. The issue over here is much diversified and complex when we go into the details of the consequences of the act. Firstly, the question arises of what is right and what is permissible? Secondly, the right of making the laws for the right and wrong act is disputed and challenged by mankind, on the basis of his reasoning and self-judgment.